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UID:calendar.21733.field_date_time.0@www.umces.edu
DTSTAMP:20260403T182831Z
CREATED:20200624T181940Z
DESCRIPTION:August 5\, 2020 3:00pm to 4:00pm    \n    \n      \n\n\n    \n
 \n              \nInstitute of Marine & Environmental Technology\n      \n
 \n\n\n\n  \n\n    \n\n              \n\n\n      \n  \n\n    \n\n          
     \n\n\nTitle: More mysteries of COVID-19 outbreak\n\n\n\nSpeaker: Dr. T
 ing-Yu Yeh (Co-Founder and Chief Scientific Officer\, Auxergen\, Inc)\n\n
 \n\nIf you would like to attend this seminar virtually\, please contact im
 etdirectorsoffice@umces.edu for the WebEx call-in information\n\n\n\nAbstr
 act: The 2019 novel coronavirus disease (COVID-19) outbreak has become a p
 ublic health emergency globally since January 2020. In addition to pneumon
 ia-like symptoms\, COVID-19 also develops a significant systemic inflammat
 ory response\, and it also attacks neurological and cardiovascular systems
 . As pandemic deepens\, SARS-CoV-2 has quickly evolved into several clades
  at different geographic areas. Whether SARS-CoV-2 variants contribute to 
 etiology and epidemiology of COVID-19 remains unclear. Here I report the e
 volution and phylogenetic analysis of SARS-CoV-2 mutations in Australia an
 d Diamond Princess cruise. Analysis of Australian SARS-CoV-2 sequences rev
 eals unusual deletions and mutations clustering in stem-loop II motif (s2m
 ) in 3’ untranslated region\, which is extremely conserved in all beta-cor
 onavirus and astrovirus during evolution. Computational analysis of Austra
 lian isolates suggests that s2m may act as the hotspot for viral RNA recom
 bination. The quarantine of Diamond Princess cruise presents an ideal stat
 ic population to measure the viral phylodynamics from the COVID-19 outbrea
 k\, providing the first insight into the de novo evolution of SARS-CoV-2 i
 n a closed population. Accelerated mutation and increased positive selecti
 on of SARA-CoV-2 are statistically significant during the quarantine perio
 d of 3 weeks. Linkage disequilibrium analysis confirmed that RNA recombina
 tion with G11083T (ORF1ab L3606F/NSP6 L37F) mutation also contributes to t
 he increase of mutations among the viral progeny in the cruise. Therefore\
 , health authorities need to revise quarantine protocols in close-quarter 
 environments.\n\n\n\nHost: Dr. Nina Lamba
DTSTART;TZID=America/New_York:20200805T150000
DTEND;TZID=America/New_York:20200805T160000
LAST-MODIFIED:20200717T203717Z
SUMMARY:Virtual IMET Seminar: Dr. Ting-Yu Yeh (Co-Founder and Chief Scienti
 fic Officer\, Auxergen\, Inc)
URL;TYPE=URI:https://www.umces.edu/events/virtual-imet-seminar-dr-ting-yu-y
 eh-co-founder-and-chief-scientific-officer-auxergen-inc
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