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DTSTART:20181104T020000
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DTSTART:20180311T020000
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UID:calendar.3117.field_date_time.0@www.umces.edu
DTSTAMP:20260405T143008Z
CREATED:20180627T150021Z
DESCRIPTION:August 29\, 2018 3:00pm to 4:00pm    \n    \n      \n\n\n    \n
 \n              \nInstitute of Marine & Environmental Technology\n      \n
 \n\n\n\n  \n\n    \n\n              \n\n\n      \n  \n\n    \n\n          
     \n\n\nTitle: The granin-derived peptide secretoneurin is a multifuncti
 onal reproductive hormone\n\n\n\nSpeaker: Dr. Vance Trudeau\, University o
 f Ottawa\n\n\n\nAbstract: Multiple neurotransmitters and neuropeptides int
 eract to control luteinizing hormone (LH) and follicle stimulating hormone
  (FSH) release from gonadotrophs in the anterior pituitary gland. The LH s
 urge is essential for fertility as it triggers ovulation in females and sp
 erm release in males. While it is well-established that gonadotropin-relea
 sing hormone (GnRH) and/or kisspeptin are required for pulsatile and surge
  release of LH in mammalian species\, their essentiality is challenged by 
 studies in the USA and Japan showing knockouts in zebrafish and medaka do 
 not block reproduction. In goldfish\, we have discovered that secretoneuri
 n a (SNa)\, a neuropeptide derived from secretogranin-IIa (SgII) processin
 g\, stimulates LH release in vivo and from dispersed pituitary cells in vi
 tro. SN does not bind to the human GnRH receptor and can enhance LH releas
 e from mouse LbetaT2 cells. Knockout of SgII genes in zebrafish indicates 
 that these genes are required for optimal reproduction. SgII knockout redu
 ces all stereotypical courtship behaviours. Spawning success is partially 
 rescued in SgII knockout fish following injection of SNa. The SN peptide s
 equence is conserved from lamprey to human\, suggesting a broader importan
 ce of this peptide family. Supported by NSERC and uOttawa-Institute of Hyd
 robiology/Chinese Academy of Sciences collaborative grants.
DTSTART;TZID=America/New_York:20180829T150000
DTEND;TZID=America/New_York:20180829T160000
LAST-MODIFIED:20180807T183905Z
SUMMARY:IMET Seminar: Dr. Vance Trudeau\, University of Ottawa
URL;TYPE=URI:https://www.umces.edu/events/imet-seminar-dr-vance-trudeau-uni
 versity-ottawa
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