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X-WR-CALNAME;VALUE=TEXT:UMCES Events
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DTSTART:20181104T020000
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UID:calendar.3119.field_date_time.0@www.umces.edu
DTSTAMP:20260405T200208Z
CREATED:20180627T150235Z
DESCRIPTION:November 7\, 2018 3:00pm to 4:00pm    \n    \n      \n\n\n    
 \n\n              \nInstitute of Marine & Environmental Technology\n      
 \n\n\n\n\n  \n\n    \n\n              \n\n\n      \n  \n\n    \n\n        
       \n\n\nTitle: Extracellular Vesicle Therapeutics\n\n\n\nSpeaker: Dr. 
 Illarion V. Turko\, Institute for Bioscience and Biotechnology Research\, 
 NIST\n\n\n\nAbstract: \n\n\n\nAll cell types have the capability to releas
 e a wide variety of membrane vesicles that are collectively designed extra
 cellular vesicles (EVs). EVs mediate intercellular communication and trans
 mit specific information from their cell of origin to their target cells. 
 As a result of this property\, EVs may serve as a drug delivering system w
 ith a strictly site-specific delivery of drug without off target side effe
 cts. Not surprisingly\, in the last decade\, EVs have emerged as a promisi
 ng new type of targeted therapeutics. However\, in comparison to existing 
 small molecule and protein therapeutics\, the EVs have much higher level o
 f complexity and current uncertainty in a broad understanding of their fun
 ctional and regulatory features has made difficult the translation from ba
 sic science to patient care.\n\n\n\nThe most challenging aspect of EVs stu
 dies is their diversity. There are multiple EVs subtypes with different bi
 ogenesis\, cargo\, and physicochemical properties. Furthermore\, EVs are i
 solated from different body fluids and in vitro cell culture media using a
  variety of general techniques\, which do not well separate subtypes of EV
 s and typically result in partially purified preparations of EVs contamina
 ted by non-vesicular components. There is an urgent need in standardizatio
 n in EVs research on all levels\, including special attention to the metho
 ds of isolation. In the present talk\, we capitalized on mass spectrometry
  based absolute protein quantitation\, and the development of a proteomic 
 tool box to assess the efficiency of EVs isolation will be presented. The 
 pilot study on using flow cytometry to isolate EVs will be presented as we
 ll. 
DTSTART;TZID=America/New_York:20181107T150000
DTEND;TZID=America/New_York:20181107T160000
LAST-MODIFIED:20181026T134037Z
SUMMARY:IMET Seminar: Dr. Illarion V. Turko\, IBBR/NIST
URL;TYPE=URI:https://www.umces.edu/events/imet-seminar-dr-illarion-v-turko-
 ibbrnist
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