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X-WR-CALNAME;VALUE=TEXT:UMCES Events
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DTSTART:20181104T020000
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UID:calendar.3120.field_date_time.0@www.umces.edu
DTSTAMP:20260423T203858Z
CREATED:20180627T150354Z
DESCRIPTION:November 14\, 2018 3:00pm to 4:00pm    \n    \n      \n\n\n    
 \n\n              \nInstitute of Marine & Environmental Technology\n      
 \n\n\n\n\n  \n\n    \n\n              \n\n\n      \n  \n\n    \n\n        
       \n\n	\n		\n			Title: The Biology of Aging - New Approaches to Old Question
 s\n			\n			Speaker: Dr. Kan Cao (Associate Professor\, University of Maryland Co
 llege Park)\n			\n			Abstract: My laboratory is interested in why and how we age
 .  Specifically\, we focus on studying molecular mechanisms of Hutchinson-
 Gilford progeria syndrome (HGPS)\, a premature aging disease\, and explori
 ng the potential connections between HGPS and normal aging. Children with 
 HGPS die at their early teens due to heart attack or stoke. Approximately 
 90% of the HGPS cases are caused by a de novo mutation at 1824 position of
  the lamin A gene (C1824T\, G608G). This mutation does not affect the code
 d amino acid\, but partially activates a cryptic splice donor site in the 
 exon 11\, leading to the production of a mutant lamin A mRNA that contains
  an internal deletion of 150 base pairs. This is then translated into a la
 min A mutant protein missing 50 amino acids near the C-terminus\, termed “
 progerin”.\n			Remarkably\, to date\, there are over 180 mutations related to
  the nuclear lamina\, and it is associated with at least 14 known human di
 seases (the laminopathies). However\, the molecular mechanisms of lamin A’
 s function still remain unclear. To investigate this question\, my laborat
 ory applies a potent suite of techniques from cell biology\, stem cell bio
 logy\, to genomics. Our goal is two-fold: (1) to develop novel treatments 
 for HGPS\; (2) to exploit our knowledge of HGPS to better understand human
  aging.\n			\n			Host: Dr.Jim Du
DTSTART;TZID=America/New_York:20181114T150000
DTEND;TZID=America/New_York:20181114T160000
LAST-MODIFIED:20181112T162156Z
SUMMARY:IMET Seminar: Dr. Kan Cao\, University of Maryland College Park
URL;TYPE=URI:https://www.umces.edu/events/imet-seminar-dr-kan-cao-universit
 y-maryland-college-park
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