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UID:calendar.3303.field_date_time.0@www.umces.edu
DTSTAMP:20260405T164851Z
CREATED:20180906T163739Z
DESCRIPTION:September 24\, 2018 1:30pm to 2:30pm    \n    \n      \n\n\n   
  \n\n              \nInstitute of Marine & Environmental Technology\n     
  \n\n\n\n\n  \n\n    \n\n              \n\n\n      \n  \n\n    \n\n       
        \n\n\nTitle: Advances in Mass Spectrometric Structural Biology Tech
 niques for Pattern Recognition Receptor Ligands of Microbial Origin\n\n\n
 \nSpeaker: Benjamin L. Oyler\, Ph.D. Candidate\, Graduate Program in Life 
 Sciences - Toxicology\n\n\n\nAbstract: Pattern recognition receptors (PRR)
  are the innate immune system’s first-line sentinels for distinguishing “s
 elf” from “non-self.” Many molecules found in the bacterial cell wall are 
 PRR ligands\, including lipopolysaccharide (LPS)\, cardiolipin (CL)\, and 
 peptidoglycan (PGN). Molecular structural biology techniques are essential
  for determining both basic cell biology and host-bacteria interactions th
 rough ligand-receptor binding mechanisms. Recent interest in designer PRR 
 ligands or PRR ligand mimetics for use in drug discovery pipelines have gi
 ven this research more translational value as well. Mass spectrometry (MS)
  has the unique capability to derive primary structures of ions as well as
  monitor many different ions in complex mixtures. Several different advanc
 es in PRR ligand structure analysis were achieved in this dissertation.\n
 \n\n\nFirst\, chemical structure of an LPS-derived vaccine was determined 
 using a top down tandem MS approach. Several different instrumental config
 urations and methods were employed to demonstrate complementarity of data 
 and broad applicability of the approach. Second\, CL from a newly discover
 ed actinomycete marine sponge symbiont was analyzed and compared to CL fro
 m a terrestrial firmicute to generate hypotheses about host-bacterium inte
 ractions. This was the first molecular analysis of any secondary metabolit
 es from this species of bacteria. Third\, PGN subunits (muropeptides) from
  Rickettsia typhi were analyzed in a data dependent global LC-tandem MS ap
 proach. This was the first example of PGN structure discovery for R. typhi
  and the first example of this approach applied to PGN structure elucidati
 on for any Rickettsia species.\n\n\n\nAll of these developments will help 
 to advance PRR-ligand interaction research – an emerging and promising fie
 ld for development of novel disease treatment and prevention approaches. M
 odulation of the innate immune response to bacterial insult is a challengi
 ng task without a clear understanding of underlying molecular mechanisms a
 nd how they might be manipulated by medicine. One key step in this process
  is development of sensitive and specific chemical analysis methods fit to
  acquire unequivocally interpretable data. While all of the methods descri
 bed herein were applied to specific biological problems\, their applicabil
 ity to other scientific questions is broad.
DTSTART;TZID=America/New_York:20180924T133000
DTEND;TZID=America/New_York:20180924T143000
LAST-MODIFIED:20180907T142334Z
SUMMARY:IMET Seminar: Benjamin Oyler Dissertation Defense
URL;TYPE=URI:https://www.umces.edu/events/imet-seminar-benjamin-oyler-disse
 rtation-defense
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