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X-WR-CALNAME;VALUE=TEXT:UMCES Events
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DTSTART:20181104T020000
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UID:calendar.3346.field_date_time.0@www.umces.edu
DTSTAMP:20260424T061649Z
CREATED:20181004T161228Z
DESCRIPTION:November 28\, 2018 1:00pm to 2:00pm    \n    \n      \n\n\n    
 \n\n              \nInstitute of Marine & Environmental Technology\n      
 \n\n\n\n\n  \n\n    \n\n              \n\n\n      \n  \n\n    \n\n        
       \n\n	\n		\n			Title: A Role for Taurine in Food Sensitivities in Fish \n			\n
 			Speaker: Mary Larkin\, Ph.D. Candidate\, UMB Toxicology\n			\n			Abstract: As th
 e aquaculture industry expands to feed an ever growing world population\, 
 it seeks  to develop more low-cost\, environmentally sustainable feed ingr
 edients.  Fish meal replacement by plant sources of protein\, including th
 ose derived from soybeans\, wheat\, and peas may have unintended effects. 
 Certain species have reacted poorly to particular ingredients\, including 
 components of soy and pea protein. We present here evidence for potential 
 negative health effects elicited by wheat gluten incorporation into the fe
 ed of Cobia (Rachycentron canadum). European sea bass (Dicentrarchus labra
 x)\, on the contrary\, seem to well tolerate this ingredient.\n			\n			We sought
  to evaluate the ability of taurine\, a known immunomodulator\, to allevia
 te inflammation in cases of adverse effects caused by particular plant ing
 redients in feed. We saw evidence for this in the cobia study\, and though
  our study did not induce any inflammation in sea bass\, we detected drama
 tically increased levels of taurine levels in the plasma of fish consuming
  a diet containing 4% wheat gluten. Supplemental taurine in European sea b
 ass shifted spectral sensitivity to a longer wavelength\, though there wer
 e no apparent anatomical differences in the retina between the un-suppleme
 nted and supplemented groups.\n			\n			We observed changes to the microbiome ind
 uced by dietary wheat gluten\, and in a separate study\, taurine. Wheat gl
 uten addition to the diet greatly increased the number of predominant phyl
 a represented in the intestinal microbiota. Taurine caused less of a shift
 \, but interestingly\, the predominant phyla were very uniform throughout 
 the sections of the intestines of the taurine-fed fish.\n			\n			In two differen
 t studies\, we attempted to characterize a dietary taurine-dependent zebra
 fish that was incapable of endogenous taurine synthesis. However\, both of
  our potential strains turned out to be producing  a wild-type CSAD (cyste
 ine sulfinic acid decarboxylase) protein even in the presence of an early 
 termination codon in the csad gene. We also observed the expression of two
  smaller sizes of CSAD\, ~53 and ~55 kDa\, in addition to the previously d
 escribed ~59 kDa protein. The two smaller sizes appear to be produced earl
 y in development and are not detectable by 3.5 weeks post-fertilization.\n
 			\n			Host: Dr. Allen Place
DTSTART;TZID=America/New_York:20181128T130000
DTEND;TZID=America/New_York:20181128T140000
LAST-MODIFIED:20181107T121149Z
SUMMARY:Dissertation Defense: Mary Larkin (Ph.D. Candidate\, UMB Toxicology
 )
URL;TYPE=URI:https://www.umces.edu/events/dissertation-defense-mary-larkin-
 phd-candidate-umb-toxicology
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