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X-WR-CALNAME;VALUE=TEXT:UMCES Events
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DTSTART:20191103T020000
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DTSTART:20200308T020000
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UID:calendar.3777.field_date_time.0@www.umces.edu
DTSTAMP:20260406T060512Z
CREATED:20190419T170020Z
DESCRIPTION:October 30\, 2019 3:00pm to 4:00pm    \n    \n      \n\n\n    
 \n\n              \nInstitute of Marine & Environmental Technology\n      
 \n\n\n\n\n  \n\n    \n\n              \n\n\n      \n  \n\n    \n\n        
       \n\n\nTitle: Epigenetics of Phenotypic Variation\n\n\n\nSpeaker: Dr.
  Aniket Gore (Staff Scientist\, NIH)\n\n\n\nAbstract: Coding and non-codin
 g mutations in DNA contribute significantly to phenotypic variability duri
 ng evolution. However\, less is known about the role of epigenetics in thi
 s process. Although previous studies have identified eye development genes
  associated with the loss-of-eyes phenotype in the Pachón blind cave morph
  of the Mexican tetra Astyanax mexicanus\, no inactivating mutations have 
 been found in any of these genes. Here\, we show that excess DNA methylati
 on-based epigenetic silencing promotes eye degeneration in blind cave A. m
 exicanus. By performing parallel analyses in A. mexicanus cave and surface
  morphs\, and in the zebrafish Danio rerio\, we have discovered that DNA m
 ethylation mediates eye-specific gene repression and globally regulates ea
 rly eye development. The most significantly hypermethylated and downregula
 ted genes in the cave morph are also linked to human eye disorders\, sugge
 sting that the function of these genes is conserved across vertebrates. Ou
 r results show that changes in DNA methylation-based gene repression can s
 erve as an important molecular mechanism generating phenotypic diversity d
 uring development and evolution.\n\n\n\nHost: Dr. Jim Du
DTSTART;TZID=America/New_York:20191030T150000
DTEND;TZID=America/New_York:20191030T160000
LAST-MODIFIED:20191003T131609Z
SUMMARY:IMET Seminar: Dr. Aniket Gore (Staff Scientist\, NIH)
URL;TYPE=URI:https://www.umces.edu/events/imet-seminar-dr-aniket-gore-staff
 -scientist-nih-0
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