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X-WR-CALNAME;VALUE=TEXT:UMCES Events
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DTSTART:20191103T020000
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UID:calendar.4833.field_date_time.0@www.umces.edu
DTSTAMP:20260405T215011Z
CREATED:20191011T155109Z
DESCRIPTION:October 23\, 2019 3:00pm to 4:00pm    \n    \n      \n\n\n    
 \n\n              \nInstitute of Marine & Environmental Technology\n      
 \n\n\n\n\n  \n\n    \n\n              \n\n\n      \n  \n\n    \n\n        
       \n\n\nTitle: Sea Urchins as Models for Aging and Cancer Research\n\n
 \n\nSpeaker: Dr. Andrea Bodnar (Science Director\, Gloucester Marine Genom
 ics Institute)\n\n\n\nAbstract: The oceans are home to many of the earth’s
  longest lived animals with several species of non-colonial marine inverte
 brates documented to live for more than 100 years. Many of these animals g
 row and reproduce throughout their lifespans with no apparent functional d
 ecline or increase in mortality rate with age. Sea urchins represent a tra
 ctable model to study the molecular\, cellular and physiological mechanism
 s underlying both lifespan determination and negligible aging. Sea urchins
  grow indeterminately\, continually regenerate damaged appendages\, and re
 produce throughout their lifespan and yet different species of sea urchins
  have very different reported lifespans ranging from 2 to more than 100 ye
 ars. Studies to date have demonstrated maintenance of telomeres\, maintena
 nce of antioxidant and proteasome enzyme activities and little accumulatio
 n of oxidative cellular damage with age in tissues of sea urchin species w
 ith different lifespans. Gene expression studies indicate that key cellula
 r pathways involved in protein homeostasis\, tissue regeneration and nerve
  function are maintained with age. Taken together\, these studies suggest 
 that long-term maintenance of mechanisms that sustain tissue homeostasis a
 nd regenerative capacity is essential for indeterminate growth and negligi
 ble aging\, and a better understanding of these processes may reveal effec
 tive strategies to prevent or treat age-related degenerative diseases in h
 umans. Maintenance of tissue homeostasis relies on the accurate regulation
  of somatic and stem cell activity to balance growth and repair of damage 
 while at the same time avoiding unchecked\, abnormal cell growth that defi
 nes cancer. As neoplasms are rarely seen in sea urchins\, they provide an 
 additional unique opportunity to understand the regulatory factors involve
 d in long-term tissue homeostasis and regeneration without conferring pred
 isposition to cancer development.\n\n\n\nHost: Dr. Sook Chung
DTSTART;TZID=America/New_York:20191023T150000
DTEND;TZID=America/New_York:20191023T160000
LAST-MODIFIED:20191011T155109Z
SUMMARY:IMET Seminar: Dr. Andrea Bodnar (Science Director\, Gloucester Mari
 ne Genomics Institute)
URL;TYPE=URI:https://www.umces.edu/events/imet-seminar-dr-andrea-bodnar-sci
 ence-director-gloucester-marine-genomics-institute
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