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X-WR-CALNAME;VALUE=TEXT:UMCES Events
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DTSTART:20191103T020000
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DTSTART:20200308T020000
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UID:calendar.4920.field_date_time.0@www.umces.edu
DTSTAMP:20260405T181245Z
CREATED:20191118T213332Z
DESCRIPTION:January 22\, 2020 3:00pm to 4:00pm    \n    \n      \n\n\n    
 \n\n              \nInstitute of Marine & Environmental Technology\n      
 \n\n\n\n\n  \n\n    \n\n              \n\n\n      \n  \n\n    \n\n        
       \n\n\nSpeaker: Dr. Daniel Nelson (Associate Professor\, University o
 f Maryland College Park)\n\n\n\nTitle: Harnessing Antimicrobial and Immuno
 therapeutic Properties of Bacteriophage Proteins\n\n\n\nAbstract: Endolysi
 ns are a class of bacteriophage-encoded peptidoglycan hydrolases that func
 tion to lyse the bacterial host cell wall in order to release progeny phag
 e. Most of these enzymes\, also known as lysins\, have one or more enzymat
 ically active domains (EADs) that cleave one of several conserved bonds in
  the bacterial peptidoglycan and a cell-wall binding domain (CBD) that bin
 ds to the bacterial surface in a species- or strain-specific manner. Signi
 ficantly\, when these enzymes are purified and added exogenously to suscep
 tible Gram-positive pathogens\, osmotic lysis and cell death can result in
  seconds\, suggesting a unique antimicrobial approach. The discovery and d
 evelopment of these enzymes as biotherapeutic agents will be discussed. To
 pics will include studies on host range\, resistance\, toxicity\, synergy\
 , pharmacokinetics\, antibody formation\, in vivo models\, and current bio
 engineering approaches to optimize these enzymes. At the end\, our most re
 cent work on fusing these enzymes with monoclonal antibodies to make speci
 es-specific immunotherapeutics will be presented.\n\n\n\nHost: Dr. Som Cha
 tterjee
DTSTART;TZID=America/New_York:20200122T150000
DTEND;TZID=America/New_York:20200122T160000
LAST-MODIFIED:20191211T185145Z
SUMMARY:IMET Seminar: Dr. Daniel Nelson (Associate Professor\, University o
 f Maryland College Park)
URL;TYPE=URI:https://www.umces.edu/events/imet-seminar-dr-daniel-nelson-ass
 ociate-professor-university-maryland-college-park
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