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X-WR-CALNAME;VALUE=TEXT:UMCES Events
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DTSTART:20191103T020000
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DTSTART:20200308T020000
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UID:calendar.4928.field_date_time.0@www.umces.edu
DTSTAMP:20260418T085718Z
CREATED:20191119T191837Z
DESCRIPTION:January 8\, 2020 3:00pm to 4:00pm    \n    \n      \n\n\n    \n
 \n              \nInstitute of Marine & Environmental Technology\n      \n
 \n\n\n\n  \n\n    \n\n              \n\n\n      \n  \n\n    \n\n          
     \n\n\nTitle: Shark thymus employs unusual antigen receptors and immuno
 genetic mechanisms \n\n\n\nSpeaker: Dr. Mike Criscitiello (Assistant Dean 
 for Research and Graduate Studies and Associate Professor of Veterinary Pa
 thobiology\, Texas A&M)\n\n\n\nAbstract: All jawed vertebrates appear to u
 se the thymus for T cell development and shaping of the primary T cell rep
 ertoire. We study the immune system of the nurse shark as it represents th
 e oldest class of animals with our immunoglobulin\, T cell receptor (TCR)\
 , MHC and thymus based adaptive immunity. While much architecture and gene
  expression is conserved between shark and mammalian thymus\, some interes
 ting differences are emerging. While somatic hypermutation is generally co
 nsidered a B cell phenomenon\, shark thymocytes employ it to diversify som
 e TCR chains\, alpha to a significant degree. This appears concentrated at
  the cortico-medullary junction\, begging questions of how positive and ne
 gative selection are influenced. TCR delta in sharks is capable of generat
 ing a few different forms. In addition to the canonical Vdelta repertoire 
 there are doubly-rearranging NARTCR that have two V domains plus the delta
  C domain\, and chimeric delta chains that use immunoglobulin heavy chain 
 variable segments along with diversity and joining segments from delta to 
 encode the variable domain. Some of these quirks of shark are also found i
 n the T cell repertoires of other vertebrate groups\, including mammals. W
 e think the TCR immunogenetics of this shark model may offer insights into
  the genesis of the system and the plasticity available in engineering ant
 igen receptor immunotherapeutics.\n\n\n\nHost: Dr. Helen Dooley
DTSTART;TZID=America/New_York:20200108T150000
DTEND;TZID=America/New_York:20200108T160000
LAST-MODIFIED:20191217T144217Z
SUMMARY:IMET Seminar: Dr. Mike Criscitiello (Assistant Dean for Research an
 d Graduate Studies and Associate Professor of Veterinary Pathobiology\, Te
 xas A&M)
URL;TYPE=URI:https://www.umces.edu/events/imet-seminar-dr-mike-criscitiello
 -assistant-dean-research-and-graduate-studies-and-associate
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